Long before its formal creation as an independent province, Quirino was the forest region of the province of Nueva Vizcaya, inhabited by tribal groups known as the Negritos. They roamed the hinterlands and built their huts at the heart of the jungle.

Quirino lies in the southeastern portion of Cagayan Valley. It is situated within the upper portion of the Cagayan River basin and bounded by Isabela on the north, Aurora on the east and southeast, and Nueva Vizcaya on the west and southwest.

The Ilocano dialect is used widely in the lowlands of the province's various municipalities while Ifugao is predominant in the uplands.

Agriculture is the main industry with rice and corn as major crops. These supply the demand of neighboring provinces and the metropolis. Banana as well as banana chips are major products sold in Metro Manila and Pampanga. Small scale industries like furniture making, basketry, rattan craft, and dried flower production are prevalent.